Dynein light intermediate chain binding

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August undefined, 2024

WebJun 5, 2024 · Cytoplasmic dynein plays crucial roles in the intracellular transport of organelles and other cargoes. Central to dynein function is the intrinsically disordered N-terminal domain of dynein intermediate chain (IC), which binds the three dimeric dynein light chains at multivalent sites, and dynactin p150 Glued and nuclear distribution … WebPhosphorylation and Pin1 binding to the LIC1 subunit selectively regulate mitotic dynein functions ... Dynein Light Intermediate Chains as …

DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 [ (human)]

WebThe dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated and the importance of individual subunits in maintaining cellular homeostasis is unknown. WebCytoplasmic dynein and dynactin are megadalton-sized multisubunit molecules that function together as a cytoskeletal motor. In the present study, we explore the mechanism of dynein-dynactin binding in vitro and then extend our findings to an in vivo context. Solution binding assays were used to define binding domains in the dynein intermediate chain (IC) and … philia coffee co

Dynein light intermediate chains as pivotal determinants …

WebCentral to the function of this motor protein complex is dynein intermediate chain (IC), which binds the three dimeric dynein light chains at … WebAug 1, 2011 · Cytoplasmic dynein consists of heavy chain (HC), intermediate chain (IC), light IC (LIC), and light chain (LC) subunits, ... The 8-kDa dynein light chain binds to … WebAug 8, 2024 · An analysis of dynein-2 subunit interactions via a visible immunoprecipitation (VIP) assay has been published, demonstrating interactions between WDR60 and TCTEX1/3-TCTEX1D2; WDR34 and LC8 and Roadblock; and the intermediate chain-light chain complex with the heavy chain and light-intermediate chain . philia agency

ATP‐induced conformational change of axonemal outer dynein …

Dynein - Wikipedia

WebCytoplasmic dynein is a member of the dynein superfamily of proteins. It is a massive multisubunit complex (1.2 MD) composed of two heavy chains (∼530 kD), three intermediate chains (74 kD), and four light intermediate chains (∼55 kD), and moves along microtubules toward their minus ends (13, 23) (Fig.5). WebMar 4, 2024 · The cytoplasmic dynein light intermediate chains (LICs) 1 and 2 are cargo-binding subunits, though their relative roles are not well understood. Here, we used in … philia childcareWebHomodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), … philia ff14

"Webically interacts with an N-terminal region of the dynein inter-mediate chain (15). The intermediate chain (74 kDa) functions as a scaffold that links the different components … " - Dynein light intermediate chain binding

Dynein light intermediate chain binding

DYNC1LI2 regulates localization of the chaperone-mediated …

Web1 day ago · Additionally, to the HC, there are several light and intermediate chains present in the ODA and IDA, alongside with light-intermediate chains for the IDA. ... Step 2: …

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WebFeb 5, 2008 · dynein light intermediate chain binding Source:GO_Central. 1 publication. Molecular Function: minus-end-directed microtubule motor activity Source:GO_Central. ... The dynein complex consists of at least two heavy chains and a number of intermediate and light chains. By similarity. Protein-protein interaction databases. BioGRID. 108107 9 ... WebMar 4, 2024 · Coil: yellow. Ribbons are thickened and non-physical struts added to make more robust for 3D printing. 6f1y-ribbon-rainbow-vis. Molecular ribbon representation with each biopolymer chain colored by rainbow from N-terminus (red) to C-terminus (blue). Intended for visualization only, not 3D printing.

WebFeb 6, 2024 · Previous studies have revealed that all tested cargo adaptors bind two subunits of dynein: the light-intermediate chain and the heavy chain [8. Lee I.-G. et al. ... which they designated the ‘heavy chain-binding site 1’ (HBS1) motif. Interestingly, both BICDR1 molecules in the structure use the HBS1 motif to interact with different dynein-A ... WebMay 20, 2024 · Adaptor binding is governed by the homologous dynein light intermediate chain subunits LIC1 (DYNC1LI1) and LIC2 (DYNC1LI2), which exist in mutually …

WebThe light intermediate chains associate in the dynein complex only as homoligomers. b ... LC4/Ca+2 binding: Related protein: ... Dynein is part of a complex including dynein … WebMar 29, 2024 · The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016] Other designations. …

WebOct 1, 2014 · Cytoplasmic dynein, a microtubule-based motor protein, transports many intracellular cargos by means of its light intermediate chain (LIC). In this study, we have determined the crystal structure of the conserved LIC domain, which binds the motor heavy chain, from a thermophilic fungus. We show that …

WebThe dynein light intermediate chain . 2. The dynein accessory proteins Lis1, Nde and Ndel-1 . This will be achieved by studying and manipulating dynein and accessory protein activity using in vitro motility assays and living tissue culture cells. Importantly, we will also investigate the role of philia and erosWebAug 26, 2024 · Binding of one dynein-2 complex to the train creates extra binding ... Hou, Y., Pazour, G. J. & Witman, G. B. A dynein light intermediate chain, D1bLIC, is required for retrograde intraflagellar ... philia assoWebMar 7, 2002 · Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning. Molecular Biology of the Cell 2011, 22 (15) , 2690 … philia biology definitionWebShop Target Dulles Store for furniture, electronics, clothing, groceries, home goods and more at prices you will love. philiac - oil warsWebJun 1, 2002 · dynein light intermediate chain binding Source:GO_Central. 1 publication. Molecular Function: microtubule motor activity Source:UniProtKB. 1 publication. ... Consists of at least two heavy chains and a number of intermediate and light chains. Protein-protein interaction databases. BioGRID. 120722 7 interactors; IntAct. Q8TD57 6 … philia bibleEach molecule of the dynein motor is a complex protein assembly composed of many smaller polypeptide subunits. Cytoplasmic and axonemal dynein contain some of the same components, but they also contain some unique subunits. Cytoplasmic dynein, which has a molecular mass of about 1.5 megadaltons (MDa), is a dimer of dimers, containing approximately twelve polypeptide sub… philia and sophiaWebically interacts with an N-terminal region of the dynein inter-mediate chain (15). The intermediate chain (74 kDa) functions as a scaffold that links the different components of the dynein motor complex, which includes the heavy chains (530 kDa), the light intermediate chains (52–61 kDa), the p150glued subunit of dynactin, and the light ... philia filosofia