Eif2a function

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August undefined, 2024

WebJan 5, 2024 · Eif2a/Eif4e double mutants showed a severe growth defect, disorganized actin cytoskeleton, and elevated actin levels, suggesting that these factors have a role in cell morphology. Expression of Eif2a downregulated Ure2 internal ribosome entry site (IRES) activity in yeast cells.

Transcriptional regulation of autophagy and its implications in …

WebApr 20, 2024 · Overall, our findings show that proper cell type-specific regulation of PERK-eIF2 signaling in DA neurons is required for normal motor and cognitive function, and that the UPR plays a critical ... WebMar 17, 2024 · Eukaryotic initiation factor 2A (eIF2A) is a single chain 65 kDa protein that was initially believed to serve as the functional homologue of prokaryotic IF2, since eIF2A and IF2 catalyze... hca wa application

The eIF2α kinases: their structures and functions

WebThe antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human eIF2a that contains serine 52. This region is conserved among many species including rat, pig, cow, fruit fly and yeast. View immunogen . Conjugate: Unconjugated ... Molecular Function: translation initiation factor. WebNov 21, 2024 · Uncharacteristic of a translation factor, eIF2A resides in the nucleus during normal growth conditions and is shuttled to the cytoplasm during cell stress. eIF2A knockout mice have shortened lifespans and develop metabolic … WebEukaryotic translation initiation factor 2A. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. EIF2A (EIF-2A) Protein … hca wage statement login

EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; EIF2A

UniProt

eIF2A is a 65 kDa protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM] It may be important for translation initiation mediated by the HCV IRES under stress conditions, but this result has been debated. Web2 days ago · STAT3 can function as a transcription factor to suppress the ... STAT3 also suppresses autophagy through interacting with and inhibiting EIF2AK2 and the subsequent phosphorylation of EIF2A, ... hca wa contactWebJan 26, 2013 · A key feature of eIF2α kinase biology is the role of both conserved and unique structural features in the determination of the … hca.wa.gov/pebb-oe

"WebMar 17, 2024 · This review summarizes our current understanding of the structure and function of a single subunit eukaryotic initiation factor 2A (eIF2A), that was initially believed to serve as the functional homologue … " - Eif2a function

Eif2a function

$eIF2A, an initiator tRNA carrier refractory to eIF2α kinases, …$

WebOct 14, 2008 · Although both of these proteins function in binding initiator tRNA to the 40S ribosomal subunit, the EIF2A protein does so in a codon-dependent manner, whereas … WebeIF2A is a single chain 65 kDa protein that was initially believed 3,4 to serve as the functional homolog of prokaryotic IF2, since eIF2A and IF2 catalyze biochemically similar reactions, i.e. they stimulate initiator methionyl-tRNA (Met-tRNA Meti) binding to the small ribosomal subunit.

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WebJun 8, 2024 · Human osteosarcoma U2OS cells stably expressing RFP-LC3 wild type (WT) and knockin for EIF2a S51A (clones 25, 59, and 70, respectively, abbreviated as C25, C59, and C70) were treated with the ... WebeIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region. ... eIF2a Imported. ORF names. CG9946 Imported. Organism names. Organism. Drosophila melanogaster (Fruit ...

WebThe phosphorylation of eIF2α is carried out by a family of four kinases, PERK (PKR-like ER kinase), PKR (protein kinase double-stranded RNA-dependent), GCN2 … WebJul 23, 2024 · After viral invasion, eIF2α phosphorylation is both advantageous and disadvantageous to cells: on the one hand, eIF2α phosphorylation shuts down protein …

WebOct 19, 2024 · Eukaryotic initiation factor 2A (eIF2A) is a 65 kDa protein that functions in minor initiation pathways, which affect the translation of only a subset of messenger … WebSep 29, 2016 · Eukaryotic initiation factor 2A (eIF2A) is a 65-kDa protein that was first identified in the early 1970s as a factor capable of stimulating initiator methionyl-tRNAi (Met-tRNAMeti) binding to 40S...

WebMar 17, 2024 · eIF2A was originally suggested to function in the same pathway, i.e., promote recruitment of Met-tRNA i to 40S ribosomal subunits [22,24]. However, its precise role, as well as the precise mechanism of its action, still remain largely enigmatic as many reports describing eIF2A function seem to contradict one another.

WebMar 29, 2024 · EIF2A eukaryotic translation initiation factor 2A [ (human)] Gene ID: 83939, updated on 29-Mar-2024. Summary. This gene encodes a eukaryotic translation … gold chiffonWebeIF2A, an initiator tRNA carrier refractory to eIF2α kinases, functions synergistically with eIF5B. The initiator tRNA (Met-tRNA i Met ) at the P site of the … gold chiffon topWebeIF2. Eukaryotic Initiation Factor 2 ( eIF2) is an eukaryotic initiation factor. It is required for most forms of eukaryotic translation initiation. eIF2 mediates the binding of tRNA iMet to the ribosome in a GTP -dependent manner. … gold chiffon scarfWebNational Center for Biotechnology Information hca.wa.gov/pebb-continuationWebPERK and eIF2a were silenced using siRNA transfection to analyze the regulation of radioresistance by PERK-eIF2a through the NF-jB signaling pathway in oropharyngeal carci-noma cells. In addition, the pathways and mechanisms under-lying this function were investigated to identify new therapeutic targets to increase the radiotherapy efﬁcacy in goldchildWebPhosphorylation of the eukaryotic initiation factor 2 (eIF2) α subunit is a well-documented mechanism to downregulate protein synthesis under a variety of stress conditions. eIF2 binds GTP and Met-tRNAi and transfers Met … gold childcareWebMay 1, 2007 · EIF2S1 is the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40S ribosomal subunit, the EIF2A protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Curated Features Showing features for repeat, region, coiled coil. Expand … gold child hospital