Web4 de jun. de 2024 · Herein, our results confirm for the first time that a reciprocal regulatory interaction exists between PFKFB3 and HIF-1α. Specifically, PFKFB3 promoted … Web18 de jun. de 2024 · Here, we establish that hIAPP misfolded protein stress activates HIF1α/PFKFB3 signaling, this increases glycolysis disengaged from oxidative …
PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases
Web8 de ago. de 2013 · Although the expression of most of these regulatory enzymes is increased by hypoxia , the PFKFB3 family member has been found to be a direct transcriptional target of HIF-1α , to be stabilized by the loss of the tumor suppressor PTEN via suppressive effects on APC/Cdh1-mediated ubiquitination , and to be activated by … Web17 de dez. de 2004 · Identification of Sequences Required for Hypoxia-inducible Transcription from the pfkfb3 Promoter—We next focused our attention on detailed … diablo 2 resurrected hurricane druid
PFKFB3 - Wikipedia
WebHypoxia-inducible factor 1 (HIF-1) is a DNA-binding protein that activates erythropoietin (Epo) gene transcription in Hep3B cells subjected to hypoxia or cobalt chloride treatment. HIF-1 DNA binding activity is also induced by hypoxia or cobalt in non-Epo-producing cells, suggesting a general role for HIF-1 in hypoxia signal transduction and transcriptional … WebMeanwhile, PFKFB3 could further enhance the phosphorylation level of ULK1 and promote autophagy in PASMCs. Moreover, intratracheal administration of adeno-miR-26a-5p … WebDetermining the expression of GLUT1 and PFKFB3, and the level of energy metabolites: ATP, ADP and AMP ... Recombinant Adenovirus-Mediated HIF-lα Ameliorates Neurological Dysfunction by Improving Energy Metabolism in Ischemic Penumbra After Cerebral Ischemia-Reperfusion in Rats . Fulltext; cinema shed